An electrographic AV optimization for the maximum integrative atrioventricular and ventricular resynchronization in CRT

Abstract Background Atrioventricular (AV) delay could affect AV and ventricular synchrony in cardiac resynchronization therapy (CRT). Strategies to optimize according optimal (AV opt-AV ) or opt-V would potentially be discordant. This study aimed explore a new optimization algorithm guided by electrograms obtain the maximum integrative effects of (opt-AV). Methods Forty-nine patients with CRT were enrolled. was measured through Ritter method. obtained yielding narrowest QRS. The considered when their difference < 20 ms, maximal aortic velocity–time integral between > ms. Results results showed that sensing/pacing (SAV /PAV correlated atrial activation time (P end-As /P end-Ap ( P 0.05). Sensing/pacing intrinsic conduction (As-Vs/Ap-Vs) 0.01). percentages more than ms differences SAV 62.9% 57.1%, respectively. Among them, linearly opt-V. sensing (opt-SAV) = 0.1 × + 0.4 70 (R 2 0.665, 0.01) pacing (opt-PAV) 0.25 PAV 0.5 30 0.560, Conclusion interval Almost half had . estimated based on electrogram parameters.